Academy of Mathematics and Systems Science, CAS Colloquia & Seminars
Speaker:
Prof. Kai Yu,Division of Cancer Epidemiology and Genetics, National Cancer Institute
Inviter:
Title:
Improve the Power of Pathway Analysis in Genetic Association Studies
Time & Venue:
2015.6.29 9:00-10:00am S309
Abstract:
It is increasingly recognized that pathway analyses-a joint test of association between the outcome and a group of single nucleotide polymorphisms (SNPs) within a biological pathway-could complement single SNP analysis and provide additional insights for the genetic architecture of complex diseases. Previously, we have developed a pathway analysis procedure called ARTP that used the adaptive rank truncated product statistic to effectively combine evidence of association over different SNPs within a pathway. In this talk, I will describe several strategies to improve the ARTP procedure. I will illustrate the advantage of the improved ARTP procedure through its applications in several large scale genome-wide association studies.
Improve the Power of Pathway Analysis in Genetic Association Studies
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